Navigating Rosacea in Pregnancy: Symptoms, Management, and Safe Treatments

Salar Hazany • May 22, 2024

Learn More About Rosacea During Pregnancy!

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Hormonal changes during pregnancy can contribute to many different skin changes. Often, this includes the worsening or development of rosacea, a common skin condition that causes flushing or long-term redness of the face due to enlarged and visible blood vessels. If you are pregnant and struggling with rosacea, you may wonder what safe treatments are available. This guide will help you understand rosacea and navigate your options. 


Prescription Rosacea Treatments Prior to Pregnancy

Rosacea is an extremely common skin condition that can affect anyone. However, you may be more prone to it if you have skin that burns easily in the sun, are between the ages of 30-50 years old, have a history of smoking, or are female. Aside from just facial redness, rosacea can create visible spider veins, swollen bumps, burning sensation, and possibly an enlarged nose in severe cases. When left untreated, many note that their rosacea worsened over time, so many afflicted individuals may want to explore different treatments early in life. Common treatments include isotretinoin, more familiarly known by the brand name Accutane®, as well as oral tetracycline antibiotics. However, these medications can be extremely dangerous for pregnant individuals due to potential risks to the fetus. Therefore, comprehending the prescription rosacea treatments prior to pregnancy is vital to outline the treatment pathway during pregnancy.


When creating a treatment plan, a standardized grading system like the mean rosacea severity score, helps in evaluation, taking into consideration both primary and secondary symptoms. Especially during pregnancy, comprehending how rosacea progresses from mild to severe forms is critical. By using the mean rosacea severity score on symptoms such as flushing, redness, papules and pustules, and spider veins, healthcare professionals can better understand the possible escalation of the rosacea condition. 


Understanding Rosacea During Pregnancy

Rosacea presents a unique challenge during pregnancy as reproductive and hormonal factors can significantly influence rosacea severity and manifestation. Approximately half of the women with pre-existing rosacea reported that it worsened during pregnancy, with about one-third experiencing no change and a minority observing that their rosacea improved. This unpredictable nature necessitates a thorough comprehension of pregnancy-induced factors that can alter rosacea’s course.


Pregnancy, a phase marked by hormonal upheaval, can significantly impact various skin conditions, including rosacea. Fluctuating levels of estrogen, progesterone, and human chorionic gonadotropin (hCG) can affect oil production and skin dryness, potentially triggering flare-ups. In particular, those undergoing progesterone therapy for pregnancy can be particularly prone to increased progression of inflammatory disorders. 


Furthermore, pregnancy is a very stressful period and the emotional state of patients can significantly impact rosacea's onset and course. Stress factors can exacerbate rosacea symptoms, with a significant number of patients experiencing stress-related flare-ups. This highlights the importance of lifestyle changes and improving emotional wellbeing, which may result in the alleviation of rosacea symptoms during pregnancy.


Managing Rosacea When Expecting

In pregnancy, managing rosacea requires balancing between effective treatment and ensuring the safety of the unborn child. The limited availability of clinical trials and concerns over potential harm to the fetus from various treatments make the task particularly challenging. However, addressing rosacea in pregnant patients both early and effectively, with careful consideration for the safety of treatments used, is crucial.


A key strategy in managing rosacea during pregnancy involves embracing safe skincare practices. Using gentle, soap-free cleansers, applying moisturizers, and protecting the skin with high-SPF, broad-spectrum sunscreen forms the basic skincare regimen. In addition, it is paramount to avoid heavy or harsh skincare products, which can exacerbate rosacea symptoms or potentially harm the fetus in pregnancy. In addition to these skincare products, adopting a low glycemic index diet and taking supplements such as Omega-3 fatty acids are recommended to help regulate oil production, reduce inflammation, and minimize skin reactivity. Topical skincare products containing hyaluronic acid, vitamin C, azelaic acid, and metronidazole are recommended during pregnancy as they have been shown to ease reported symptoms of rosacea without harmful effects on the fetus.


Complications & Comorbidities

Rosacea during pregnancy isn’t merely a skin condition. It can be associated with other health issues, such as diabetes, heart problems, and inflammatory bowel disease, potentially adding to the complexity of patient management. These complications may be due to overlapping inflammatory pathways. 


Rosacea fulminans, also known as pyoderma faciale, is a rare dermatologic disease recognized as an uncommon presentation of rosacea. Rosacea fulminans can sometimes develop during pregnancy and is associated with differing obstetric outcomes. It is characterized by red bumps, pustules, and thick plaques that are mainly localized on the face, which can cause severe emotional trauma when prolonged. Rosacea fulminans also typically has a sudden onset and can be associated with draining sinuses. Furthermore, rosacea fulminans is almost completely confined to females, especially during pregnancy, with little data on occurrence in males. 


These linkages emphasize the need for an all-encompassing strategy in managing rosacea during pregnancy, not only considering just the skin condition but also potential systemic implications and emotional trauma. While many traditional rosacea treatment options are not suitable during pregnancy, there are some oral corticosteroids and azithromycin that patients have taken and noted their rosacea improved. Furthermore, topical metronidazole used in combination with other therapies has shown success.


Treatment Options Beyond Topicals

In terms of treating rosacea during pregnancy, the alternatives extend past topical applications. However, the choice of treatment is complex due to a lack of extensive randomized controlled trials and potential harm to the fetus from many treatments.


Oral doxycycline, commonly used for rosacea, is not recommended during pregnancy, making azithromycin a safe oral treatment alternative for pregnant patients. On the topical front, azelaic acid can serve as an alternative treatment for rosacea in pregnant patients, effectively reducing erythema and inflammation, with a favorable safety profile. These alternatives underline the need for early and aggressive treatment of rosacea during pregnancy while still prioritizing both successful treatment and the baby's safety.


Due to its severity, rosacea fulminans in a pregnant patient may necessitate the consideration of systemic steroids. However, their usage during pregnancy carries many risks. For the fetus, there is a possibility of intrauterine growth retardation. For the mother, the use of systemic steroids can increase the risk of complications in pregnancy such as maternal diabetes mellitus and hypertension. Therefore, the administration of systemic steroids emphasizes the need to strike a balance between efficacious treatment of rosacea severity while safeguarding both the mother and fetus.


In the quest for effective rosacea treatments during pregnancy, alternative therapies have gained attention. Topical ivermectin is one such alternative therapy for treating rosacea. Clinical studies indicate that topical ivermectin has demonstrated greater effectiveness than metronidazole in treating rosacea. However, its use during pregnancy is accompanied by heightened concerns. This draws attention to the need for continued research to discover safe and efficacious treatments for managing rosacea severity while pregnant.


Additionally, there are certain lasers that can be used to eliminate the enlarged blood cells that cause rosacea, thus eliminating the redness. However, only a few lasers are safe to use on rosacea during pregnancy. At our clinic, we do offer a special Nd:YAG laser that can be used to treat rosacea in pregnant patients. However, it is vital to first discuss your health history and more with our providers in order to determine safety and suitability for your pregnancy. 


Conclusion

Navigating rosacea during pregnancy is a journey of understanding, patience, and personalization. The interplay between pregnancy-related hormonal changes, rosacea severity, and the risks and benefits of treatments all contribute to this complex condition. However, with the right knowledge, support, and personalized treatment plans, it is possible to effectively manage. Keep in mind, every pregnancy is unique, and so is every journey with rosacea. 

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With the advancement of acne therapies through extensive research, technology, and pharmacology, the market for acne treatment products has become extremely saturated. This market saturation has made it hard for consumers to identify the best products for their skin. While each patient’s skin is different and requires a unique combination of treatments, there are a couple of widely available over-the-counter (OTC) home remedies that have proven to be effective on a majority of skin types. Dr. Salar Hazany, a board-certified and well-established dermatologic surgeon, recommends exploring some of the following treatments and remedies to see which is the most compatible with your skin. Since every skin type responds differently to treatments, there is no particular ranking of efficacy for the following: #1 Benzoyl Peroxide Benzoyl peroxide is a popular recommendation backed by dermatologists. It is a highly effective ingredient for killing bacteria and clearing the skin of waste and dead skin cells, all of which clog pores and cause acne. It is also a very strong exfoliating agent that works synergistically with other products to treat acne-prone skin. Benzoyl peroxide, however, doesn’t work for all types of acne. Specifically, non-inflammatory acne, including comedones and whiteheads generally do not respond much to benzoyl peroxide’s mechanism of action. Other topicals, such as salicyclic acid (as described below), are better alternatives to benzoyl peroxide. There are many forms of benzoyl peroxide available, including topical gels, foams, and creams. It is important to apply a small amount only on the affected areas, unless otherwise instructed, as this is a strong chemical. Before doing so, however, it is important to test the product on a few spots first to see how your skin reacts. Because benzoyl peroxide is an exfoliant, it can cause extreme dryness and redness on the skin. Patients should adhere to the most minimal dosage recommended, as higher doses are not necessarily going to yield better acne reduction. In addition, benzoyl peroxide is a bleaching agent that can discolor fabrics that come into contact with the treated skin. #2 Salicylic Acid A comparable alternative to benzoyl peroxide is salicylic acid, a topical peel that is especially effective against comedonal acne, such as blackheads and whiteheads. Salicylic acid is a beta hydroxy acid, a more penetrative version of alpha hydroxy acids that goes deep into clogged pores. Beta hydroxy acids are oil-soluble, meaning they can pass through the lipid layer of the stratum corneum, the top layer of the epidermis, to remove dead skin cells and excess oil trapped in the pores of the dermis. Although salicylic acid is an efficacious treatment for comedonal acne, benzoyl peroxide is still more effective for treating acne lesions that are more pustular in nature, due to its unique potent anti-inflammatory and antimicrobial properties. However, it is generally not recommended to use both products at the same time, as this could lead to severe dryness and redness. It is best to apply a sparing amount of each product on different days to avoid these side effects. Benzoyl peroxide and salicylic acid are found in many over-the-counter medications sold at local pharmacies. Benzoyl peroxide and salicylic acid medications come in concentrations of 2.5%, 5%, and 10% and 0.5% to 2% respectively. It is best to speak with your dermatologist to see what concentrations are optimal for treating your particular skin issues. #3 Glycolic Acid Glycolic acid is a type of alpha hydroxy acid that gently exfoliates the skin. Its mild effects make them great treatment options for acne-prone patients who also struggle with sensitive skin. These are plant-derived acids often utilized in anti-aging serums and creams marketed to older patients who want to treat their age/sun spots or just general discoloration of their skin. Because glycolic acid is not as strong as most facial chemical peels, it is quite limited in its application. It can surely prevent acne breakouts by clearing pores and removing impurities on the skin, but it is not potent enough to treat acne scars. At most, it can treat any hyperpigmentation associated with scars but will do little to the actual texture. If you are looking for an even more gentle alternative, lactic acid is also a good exfoliant as well as a hydrator. One downside is that the results will not be as noticeable at such a low strength. However, with multiple sessions, you can expect to see a considerable difference in your skin. #4 Vitamin C Vitamin C serums have also gained tremendous momentum as a skincare oral supplement. While benzoyl peroxide is considered the holy grail of acne treatment, more recent research suggests that Vitamin C serums are a much better alternative for certain skin types. Because Vitamin C is a 100% natural ingredient, it can lead to better results for people with sensitive, easily inflammable, or irritable skin. While benzoyl peroxide is praised for its antiseptic and exfoliating properties, Vitamin C is a potent antioxidant, protecting your skin from oxidative damage from the sun while also boosting collagen production at the same time. Regular Vitamin C supplementation is thus one of the most important habits to develop to prevent not only premature aging of the skin but also skin cancer. #5 Ointments, and Lotions (Hydrocortisone) Hydrocortisone is an FDA-approved drug for inflammatory skin conditions that cause swelling, itching, and irritation of the skin. For patients that are currently experiencing psoriasis, eczema, or other irritable skin conditions, hydrocortisone (1%) OTC medication is a safe, low-dose, topical steroid medication that can provide temporary relief to the symptoms listed above. At the biochemical level, hydrocortisone essentially mimics cortisol, a natural hormone released during periods of high stress. Cortisol plays a major role in the regulation of carbohydrates, fats, and proteins as well as other sympathetic nervous system fight-or-flight responses, including the body’s natural inflammatory response to high-stress situations. Hydrocortisone can act as a hormone replacement to treat other cortisol deficiencies, like adrenal insufficiency and hypopituitarism. In low concentrations, hydrocortisone is an effective measure against dry, rashy, and irritable skin. In addition to hydrocortisone, there are other commonly used topical corticosteroids available for patients to buy OTC, including triamcinolone, fluocinonide, and clobetasol. Before starting these medications, however, it is recommended that you consult a board-certified dermatologist to ensure proper application and dosage of the topicals listed above. Honorable Mentions and Alternatives #1 Tea Tree Oil While there are many conventional methods of treating acne, especially with creams and prescribed medications, essential tea tree oil is a natural remedy that really works! While there are still clinical trials being completed to extensively study the effects of tea tree oil, many researchers have concluded it is an effective antibacterial and anti-inflammatory remedy. In particular, its anti-inflammatory properties are conferred by its primary constituent, terpinene-4-ol, a known suppressor of pro-inflammatory mediators released by a specific kind of white blood cell, called monocytes. These monocytes are naturally activated when bacteria accumulate in clogged pores, resulting in vasodilation and inflammation. When tea tree oil is applied to the affected area, it penetrates deep into the dermis to kill the bacteria and calm the body’s naturally prolonged immune response. #2 Aloe Vera Another common herbal home remedy for skin is aloe vera, a topical gel-like substance derived from plants. Acting as a natural antibacterial and anti-inflammatory agent that can reduce the appearance of acne and prevent acne outbreaks, it is a popular alternative to conventionally prescribed medications. Because aloe vera is derived from a plant, it naturally contains a lot of water and is an ideal moisturizer for people who get dry skin from the usage of other non-compatible acne products. While there are many home mixtures of aloe vera and tea tree oil with other moisturizers, it is important to get a consultation with qualified professionals and see which one might work the best for you. Key Takeaways and Reminders While these remedies are often advertised as easy quick-fixes, it is important to recognize that each individual skin type is different and requires specialized treatments. Here are some recommended tips that should be practiced for all skin types. It is important to practice regular everyday skincare routines, such as washing your face twice a day, applying sunscreen before exposure to sunlight, avoiding touching your face with dirty hands, or following a dermatologist-recommended skin care regimen. In addition, regular exfoliation is helpful to not only improve skin tone but also reduce the appearance of dark spots, scars, and other irregularities over time. Regular exfoliation will also help in removing dead skin follicles, bacteria, and oil. There are many facial wash options on the market, so make sure to do your research before committing to a purchase. Before taking any medications, over-the-counter drugs, supplements, or herbs, consult a physician for a thorough evaluation. We do not endorse any medications, vitamins, or herbs. A qualified physician should make a decision based on each person’s medical history and current prescriptions. The medication summaries provided do not include all of the information important for patient use and should not be used as a substitute. Remember that although acne is a persistent and stubborn problem for many patients, we truly believe that every case of acne can be cured. Schedule your consultation today to achieve your desired skin results and let our team help you!
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